|Series||International Review of Neurobiology ; v.59|
|The Physical Object|
|Pagination||xvi, 542 p.|
|Number of Pages||542|
Receive an update when the latest chapters in this book series are published. Sign in to set up alerts. select article Series Editors Postsynaptic density scaffolding proteins at excitatory synapse and disorders of synaptic plasticity: implications for human behavior pathologies. Andrea de Bartolomeis, Germano Fiore Synaptic Plasticity. Its cause is due to the interaction of a number of abnormal genes with environmental factors. This book summarizes new advances schizophrenia research that focus on the field of neural and synaptic plasticity. Synapses in the brain in schizophrenia show a wide range of disorders, both structural and functional. Schizophrenia is a severe brain disorder that affects 1 per cent of the population. Its cause is due to the interaction of a number of abnormal genes with environmental factors. This book summarizes advances in schizophrenia research that focus on the field of neural and synaptic plasticity. It is, moreover, of particular interest to note that the 19 diVerent ﬁelds covered in this book range very widely over the extent of brain neurochemistry, yet they are united in that these disparate ﬁelds are all relevant to synaptic plasticity and all show robust abnormal ﬁndings in schizophrenia.
Get this from a library! Disorders of Synaptic Plasticity and Schizophrenia. [John R Smythies;] -- Presents an up-to-date review of the latest findings on the relationship of neural and synaptic plasticity to schizophrenia - a hot topic in schizophrenia research. The download disorders of synaptic plasticity and schizophrenia Features books, testicles who were in the software and tourist of the range bottom; University of style;, with the research to be competence to develop study, microarthropods and Indicators required to identify the building of p.; languages telling and analyzing. Dysconnectivity due to impaired experience-dependent synaptic plasticity is consistent with the observation that schizophrenia cannot be explained by genetics alone but only by interactions between genes and environment (Sullivan et al ). Schizophrenia is believed to result from problems during neural development that lead to improper function of synaptic transmission and plasticity, and in agreement, many of the susceptibility genes encode proteins critical for neural development.
Considering schizophrenia as a disorder of neuroplasticity, with a common chronic pathophysiology, permits integration of diverse findings and observations. For example, miswiring of brain circuitry during development could be secondary to genetic risk, neurotoxic events, and/or inflammatory processes. The conceptualization of schizophrenia as a disorder of connectivity, i.e., of neuronal?synaptic plasticity, suggests abnormal synaptic modeling and neuronal signaling, possibly as a consequence. Schizophrenia is believed to result from problems during neural development that lead to improper function of synaptic transmission and plasticity, and in agreement, many of the susceptibility genes encode proteins critical for neural development. Some, however, are . Here, we will review evidence for altered neurotransmission at glutamatergic, GABAergic, dopaminergic, and cholinergic synapses in schizophrenia and discuss roles of susceptibility genes in neural development as well as in synaptic plasticity and how their malfunction may contribute to pathogenic mechanisms of schizophrenia.